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SoothePaws Dog Calming Pheromone Refills 2-pack 2 refill bottles, 60 days of continuous calm for anxious dogs, fits all SoothePaws diffusers

SoothePaws Dog Calming Pheromone Refills 4-pack 4 refill bottles, 120 days of dog anxiety relief, save 11% on continuous calm

SoothePaws Dog Calming Pheromone Refills 6-pack 6 refill bottles, 180 days of whole-home calm for dogs, best value save 22%

SoothePaws Dog Calming Pheromone Refills 8-pack 8 refill bottles, 240 days of multi-room dog anxiety relief, bulk save

Dog Calming Diffuser Refills, 2/4/6/8 Pack | SoothePaws

Golden retriever sleeping on sofa with SoothePaws pheromone refill on side table and diffuser plugged into wall calm dog at home in warm living room

How SoothePaws Dog Calming Refills work in 4 steps screw refill into diffuser, dog detects calming scent, scent signals calm to brain, dog relaxes and rests

SoothePaws 14-Night Calm Test guarantee full refund if your dog is not calmer, no returns required, keep the diffuser

Dog anxiety transformation with SoothePaws refills — pacing becomes sleeping, hiding becomes relaxed, barking becomes calm, cowering becomes settled rest

SoothePaws Dog Calming Refills safety proof — no drugs, no sedatives, no essential oils, safe around children and other pets, vet-informed pheromone formulation

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Dog Calming Diffuser Refills, 2/4/6/8 Pack | SoothePaws

Name: Dog Calming Diffuser Refills, 2/4/6/8 Pack | SoothePaws
Brand: SoothePaws
Price: 29.99 USD
Availability: InStock
Rating: 4.6 (5 reviews)

(5)

Compatible with SoothePaws Calming Diffuser only · each refill lasts 30 days

When your refill runs out, the pheromone signal stops — your pet's stress response can return within 48 hours. Keep a refill ready before the current one empties.

The pheromone calming effect only works when it's continuous. The day your diffuser runs out, the pheromone signal stops. Your.

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Choose your supply

2 refills 60 days

4 refills 120 days

6 refills 180 days

8 refills 240 days

60 days of calm

1 room covered

14-Night test

BEST VALUE — RECOMMENDED

Subscribe & Save 2 refills shipped Pause or cancel anytime

/day · /refill

✓ 2 refills shipped

✓ Free US shipping

✓ Ships in 1 business day

✓ Pause or cancel anytime

✓ Cancel in one click

One-time purchase Ships in 1 business day · 14-Night Calm Test

per refill

per day

of calm

Or 4 payments of Shop Pay · no fees

Quantity

Free shipping on orders $49+

60-days money-back guarantee

Ships within 1 business day

(5)

The pheromone calming effect only works when it's continuous.

The day your diffuser runs out, the pheromone signal stops. Your dog's stress response can return within 48 hours. Every pet parent who's experienced it once never forgets it. The pacing comes back. The door-scratching comes back. The indoor accident comes back. The 60 days of calm you've built quietly unwinds in a weekend.

Refills exist to make that impossible. Set up Subscribe & Save and a fresh 2-pack arrives every 60 days at 20% off. The diffuser never runs dry, the calm never breaks, and you never think about it. Most pet parents who've been on SoothePaws for 6+ months are subscribers.

Each refill lasts 30 days of continuous use. Swap it into your existing SoothePaws diffuser when the liquid runs out. That's the entire workflow.

CHOOSE YOUR SUPPLY (THE 4-TIER PACK LADDER)

PACK	COVERAGE	BEST FOR	SUBSCRIBE PRICE	ONE-TIME PRICE
2-pack	60 days, 1 diffuser	Single-pet, single room. Trying the system.	$29.50, save 10%	$32.99
4-pack	120 days, 1 diffuser	Single-pet, longer runway	$54.99, save 17%	$59.99
6-pack	180 days, 1 diffuser	Best mid-tier value	$60.00, save 20%	$74.99
8-pack	240 days, 1 diffuser, OR 60 days for 4 diffusers	Best per-day cost. Multi-room homes.	$74.99, save 25%	$89.99

Pricing note for founder: 2-pack and 6-pack prices are locked from the original spec. 4-pack and 8-pack prices are strategist proposals based on the existing savings curve. Adjust before publishing if needed.

THE 48-HOUR WARNING (URGENCY CALLOUT, RENDERS INSIDE BUY BOX)

WHY SUBSCRIBERS NEVER RUN OUT

When your refill runs out, the pheromone signal stops. Your dog's stress response can return within 48 hours. Subscribe & Save delivers a fresh 2-pack every 60 days at 20% off, so the calming never breaks. Cancel or pause anytime from your account.

SUBSCRIBE & SAVE 20% (THE OFFER)

Set it and forget it. A 2-pack arrives every 60 days at 20% off, automatically. Pause, skip, or cancel from your account in two clicks. No phone call. No retention dance. Most subscribers haven't had to think about refills since the day they signed up.

§J. HOW IT WORKS (UNIVERSAL 4-STEP)

STEP	TITLE	WHAT HAPPENS
1	Swap	When the diffuser runs dry, unscrew the empty vial and screw in the new refill. Takes 10 seconds.
2	Plug in	Leave the diffuser running 24/7. The pheromone releases continuously at low concentration.
3	Detect	Your dog's vomeronasal organ picks up the DAP signal within hours of refill replacement.
4	Continue	The calming effect picks up exactly where the last refill left off. No re-acclimation period.

WHO SUBSCRIBES (REAL SUBSCRIBER PROFILES)

Rescue parents who've finally hit a stable routine and won't risk breaking it

Multi-pet households where stress in one dog cascades into the others

Pet parents in apartments where indoor marking is non-negotiable

Pet parents who travel. Set the subscription, forget the inventory.

Anyone who's had the diffuser run out and watched a week of progress disappear

COMPATIBILITY

Compatible only with the SoothePaws Calming Diffuser. Don't have one yet? Shop the Dog Diffuser Starter Kit.

Refills work in any SoothePaws diffuser regardless of purchase date

Each refill is single-pet, single-diffuser. For multi-room calm, use one diffuser plus refills per main room.

3-year shelf life from manufacture date, printed on the outer box of every refill

SPECS

COMPATIBILITY	SoothePaws Dog Calming Diffuser only
REFILL LIFE	30 days continuous use per refill
PACK SIZES	2, 4, 6, 8
ACTIVE INGREDIENT	Synthetic analog of Dog Appeasing Pheromone (DAP)
ODOR	Odorless to humans. No fragrance. No essential oils.
SHELF LIFE	3 years from manufacture date (printed on outer box)
SUBSCRIBE & SAVE	20% off. Auto-refill every 60 days. Cancel anytime.
GUARANTEE	14-Night Calm Test on first order. Keep the diffuser if it doesn't work.
SHIPPING	Ships in 1 business day. US and UK warehouses.

How SoothePaws calms in 4 simple steps

1

Detect

Pheromone signal released into the air — species-specific, odorless to humans.

2

Drain

Nervous system receives safety signal, cortisol and adrenaline begin to drop.

3

Quiet

Stress response quiets — heart rate slows, body relaxes, breathing deepens.

4

Ease

Behavior improves naturally — less barking, no accidents, calmer demeanor.

SoothePaws vs Feliway Treats Training Sedatives
Same proven pheromone science. A different experience around it.

Features SoothePaws Treats Sprays Training

Drug-free formula Synthetic DAP / F3 pheromone (specified) "All-natural vapor" (not publicly specified) Synthetic DAP / F3 pheromone CBD, L-theanine, tryptophan
24/7 Passive coverage Synthetic DAP / F3 pheromone (specified) "All-natural vapor" (not publicly specified) Synthetic DAP / F3 pheromone CBD, L-theanine, tryptophan
Effortless administration Synthetic DAP / F3 pheromone (specified) "All-natural vapor" (not publicly specified) Synthetic DAP / F3 pheromone CBD, L-theanine, tryptophan
Safe for kids & environment Synthetic DAP / F3 pheromone (specified) "All-natural vapor" (not publicly specified) Synthetic DAP / F3 pheromone CBD, L-theanine, tryptophan
Fast results (< 7 days) Synthetic DAP / F3 pheromone (specified) "All-natural vapor" (not publicly specified) Synthetic DAP / F3 pheromone CBD, L-theanine, tryptophan

Drug-free formula

SoothePaws

Synthetic DAP / F3 pheromone (specified)

Treats

"All-natural vapor" (not publicly specified)

Sprays

Synthetic DAP / F3 pheromone

Training

CBD, L-theanine, tryptophan

24/7 Passive coverage

SoothePaws

Synthetic DAP / F3 pheromone (specified)

Treats

"All-natural vapor" (not publicly specified)

Sprays

Synthetic DAP / F3 pheromone

Training

CBD, L-theanine, tryptophan

Effortless administration

SoothePaws

Synthetic DAP / F3 pheromone (specified)

Treats

"All-natural vapor" (not publicly specified)

Sprays

Synthetic DAP / F3 pheromone

Training

CBD, L-theanine, tryptophan

Safe for kids & environment

SoothePaws

Synthetic DAP / F3 pheromone (specified)

Treats

"All-natural vapor" (not publicly specified)

Sprays

Synthetic DAP / F3 pheromone

Training

CBD, L-theanine, tryptophan

Fast results (< 7 days)

SoothePaws

Synthetic DAP / F3 pheromone (specified)

Treats

"All-natural vapor" (not publicly specified)

Sprays

Synthetic DAP / F3 pheromone

Training

CBD, L-theanine, tryptophan

Comparison based on publicly available information as of May 08, 2026. Adaptil® and Feliway® are registered trademarks of Ceva Santé Animale. TheraPetMD® is a trademark of its respective owner. SoothePaws is not affiliated with, endorsed by, or sponsored by Ceva Santé Animale or TheraPetMD. All product claims are based on the cited peer-reviewed research available on our Science page. Individual pet response to pheromone calming varies.

Features	SoothePaws	Treats	Sprays	Training
Drug-free formula	Synthetic DAP / F3 pheromone (specified)	"All-natural vapor" (not publicly specified)	Synthetic DAP / F3 pheromone	CBD, L-theanine, tryptophan
24/7 Passive coverage	Synthetic DAP / F3 pheromone (specified)	"All-natural vapor" (not publicly specified)	Synthetic DAP / F3 pheromone	CBD, L-theanine, tryptophan
Effortless administration	Synthetic DAP / F3 pheromone (specified)	"All-natural vapor" (not publicly specified)	Synthetic DAP / F3 pheromone	CBD, L-theanine, tryptophan
Safe for kids & environment	Synthetic DAP / F3 pheromone (specified)	"All-natural vapor" (not publicly specified)	Synthetic DAP / F3 pheromone	CBD, L-theanine, tryptophan
Fast results (< 7 days)	Synthetic DAP / F3 pheromone (specified)	"All-natural vapor" (not publicly specified)	Synthetic DAP / F3 pheromone	CBD, L-theanine, tryptophan

Got Questions?

Safety questions

Yes. SoothePaws uses synthetic analogs of the pheromones that pets naturally produce. Pheromones are species-specific — dog pheromones don't affect cats or humans, and vice versa. There's no airborne drug, no sedative, and no fragrance that children or adults can detect. The formulation has been reviewed by our veterinary advisory team and is considered safe for homes with babies, children, and adults with sensitivities.

Yes. SoothePaws contains no essential oils — many of which (tea tree, eucalyptus, citrus, peppermint) are toxic to cats. The synthetic pheromone is designed to be detected by your cat's vomeronasal organ without any ingestion risk. Even if your cat rubs against the diffuser or licks a surface nearby, there's no toxicity concern.

Yes. Dog pheromones and cat pheromones are species-specific — the dog diffuser has no effect on cats, and the cat diffuser has no effect on dogs. In multi-pet households, we recommend one diffuser per species in the rooms they use most.

Yes. The formulation is drug-free and non-pharmaceutical. However, if your pet is pregnant, nursing, or on prescription medication, we recommend checking with your own veterinarian before starting any calming product.

Effectiveness questions

Most pet parents notice calmer behavior within 7 to 14 days of continuous use. Some see a shift within 48 hours; others need a full 30 days before the change is consistent. The key is continuity — leave the diffuser plugged in 24/7 for at least the first 30 days to give your pet's nervous system time to adjust.

We back every order with our 14-Night Calm Test. If you don't see a change in your pet's behavior after 14 nights of continuous use, email us within 60 days for a full refund. You don't need to return the diffuser or refills — just let us know it didn't work and we'll refund your order.

No. SoothePaws is not a sedative. It doesn't slow your pet down, dull their energy, or change who they are. What it does is reduce the stress response — so the anxious, reactive, or fearful behavior quiets. Your pet is still the same pet, just less afraid.

Practical questions

One diffuser covers up to 700 square feet. For most apartments and small homes, one is enough. For larger homes or multi-story houses, use one per main floor. For multi-pet households where pets spread across the house, use one per main room each pet uses.

30 days of continuous use per refill. Our Starter Kit includes 2 refills (60 days total); our 6-pack gives you 180 days. Most pet parents set up Subscribe & Save so they get a new 2-pack automatically every 60 days at 20% off.

YES. We ship to the USA, the UK, and Worldwide. All orders are dispatched within one business day from our local warehouses in California and Birmingham.

SoothePaws is drug-free and designed to be compatible with most veterinary protocols. However, if your pet is on prescription anxiety medication, we recommend checking with your own vet before starting any calming product — they may want to adjust dosage as your pet responds to the pheromone support.

All three use synthetic pheromone analogs — Adaptil and SoothePaws for dogs (Dog Appeasing Pheromone), Feliway and SoothePaws for cats (Feline Facial Pheromone). The peer-reviewed research supporting pheromone calming applies equally to all three. What differs is the product experience: SoothePaws is built direct-to-consumer, backs every order with a 14-Night Calm Test guarantee, offers Subscribe & Save pricing, and ships in 2 days from US and UK warehouses. Adaptil and Feliway are built for the veterinary clinic channel. For a full side-by-side, see our comparison page.

Each 30-day refill is designed for continuous use from the moment you plug it in. Unopened refills have a 3-year shelf life from the manufacture date printed on the box — but most customers on Subscribe & Save go through them well before that. Once a refill is plugged in and running, it lasts the full 30 days at consistent strength.

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Calm + Groom Bundle for Dogs, Save 30% | SoothePaws

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Dog Calming Diffuser Starter Kit, 60 Days | SoothePaws

$49.99

Try it risk-free for 14 nights.

Not calmer? Full refund. Keep the diffuser.

Cart

Dog Calming Diffuser Refills, 2/4/6/8 Pack | SoothePaws

Add a second room Subscriber exclusive

What SoothePaws Solves

How SoothePaws calms in 4 simple steps

Detect

Drain

Quiet

Ease

SoothePaws vs Feliway Treats Training Sedatives

Got Questions?

Safety questions

Is SoothePaws safe around children and babies?

Is it safe if my cat licks or grooms near the diffuser?

Can I use the dog diffuser and cat diffuser in the same house?

Is it safe for pregnant or nursing pets?

Effectiveness questions

How fast will I see results?

What if it doesn't work for my pet?

Will it change my pet's personality?

Practical questions

How many diffusers do I need?

How long does a refill last?

Do you ship to my country?

Can I use SoothePaws alongside my vet's prescribed medication?

What's the difference between SoothePaws and Adaptil or Feliway?

How long does SoothePaws stay fresh?

Similar Products

Calm + Groom Bundle for Dogs, Save 30% | SoothePaws

Dog Calming Diffuser Starter Kit, 60 Days | SoothePaws

Try it risk-free for 14 nights.

Cart

Dog Calming Diffuser Refills, 2/4/6/8 Pack | SoothePaws

Add a second room Subscriber exclusive

Share this product

What SoothePaws Solves

How SoothePaws calms in 4 simple steps

Detect

Drain

Quiet

Ease

SoothePaws vs Feliway Treats Training Sedatives

Got Questions?

Safety questions

Is SoothePaws safe around children and babies?

Is it safe if my cat licks or grooms near the diffuser?

Can I use the dog diffuser and cat diffuser in the same house?

Is it safe for pregnant or nursing pets?

Effectiveness questions

How fast will I see results?

What if it doesn't work for my pet?

Will it change my pet's personality?

Practical questions

How many diffusers do I need?

How long does a refill last?

Do you ship to my country?

Can I use SoothePaws alongside my vet's prescribed medication?

What's the difference between SoothePaws and Adaptil or Feliway?

How long does SoothePaws stay fresh?

Similar Products

Calm + Groom Bundle for Dogs, Save 30% | SoothePaws

Dog Calming Diffuser Starter Kit, 60 Days | SoothePaws

Try it risk-free for 14 nights.